Consider FIT
Hands come in all shapes and sizes, palm widths, finger length and strength, natural thumb position, etc.
Caliber, size, weight, round capacity, felt recoil, trigger pull weight, grip size, strength required to rack the slide - these are all factors to consider when choosing a firearm for yourself or another. When considering a long gun purchase, add arm length to the proper fit.
For example, a .22LR revolver is light, holds 9-11 rounds, has light felt recoil, but has 9-12 pounds of trigger pull weight (think about lifting a gallon of milk with your index finger).